Statins

I visited a primary care physician for the first time in about four years. The last time I visited one was before coming to Alabama. My blood work came back showing that my previously OK cholesterol levels had gone ballistic. I attribute the jump to getting cozy with the southern diet. Too much BBQ, too many chicken fingers. So the bad news is that the good times of ignorantly eating and drinking to my heart's (dis)content are over. Better to know now than to find out in the emergency room, I suppose. So what does this have to do with fungi? It has to do with the prescription the doctor handed me.

As it turns out, the cholesterol-lowering wonder drugs of the 21st century, statins, were originally derived from fungi. Now mainly synthesized, these drugs work by inhibiting a key enzyme in cholesterol production, HMG-CoA reductase. Some of the first research on statins was performed by Dr. Akira Endo, a biochemist, who found cholesterol-inhibiting compounds in Penicillium citrinum. Penicillium spp., besides being very common mold agents, also gave us the first antibiotic discovery, penicillin.
Endo and Masao Kuroda hypothesized that Fungi could defend themselves from other organisms by inhibiting cholesterol production, and fortunately for millions of people, they were correct.
The ability to produce statins is apparently widespread throughout the true Fungi, even the oyster mushroom is naturally high in lovastatin (link to PDF). Antibiotics and statins, two of the most important medical discoveries of the past 100 years. Thanks, Fungi!


Update-1/19/10. I just found this article, which may help defuse one of the problems with statins, the grapefruit juice contraindication. The answer? more edible fungi, of course!

On or about this data in Alabama fungal history...

George Washington Carver died. The 'Black Leonardo' is most famous for his work with peanuts, making darn near everything with them, he got his start at the institution which is now Iowa State University, where he earned his Master's degree, and worked in plant pathology and mycology. What did he do? I surely don't know. But given his status among the luminaries that Alabama may claim (having taught just down the road at Tuskegee Institute), I'd like to pay homage.

Another great Alabama local commercial

Another great local commercial.

Phyllotopsis nidulans

Just got out in the woods yesterday. Probably my last time at this site over near Tuscaloosa. I came upon these lovely orange babies on a snag.
They look superficially like oysters, but on pine? No, these are the orange mock oyster, Phyllotopsis nidulans. Astipitate (without a stipe or stalk), on wood, these ones didn't smell fetid to me though they are reported to be nasty smelling. The pileus is fluffy in appearance on the top.


I just recently discovered another mycoblog, Mycorant. They have a link to my blog (thanks!) and do have some of the same material (i.e. fungal news), but a lot more of it. Did they get the inspiration for the name from looking upon my blog? Maybe. I'd like to think that imitation is the sincerest form of flattery. I recommend checking it out.

Ridiculous

One of my goals in writing this blog is to act as ombudsman for fungi. Why? Because fungi are, in my mind, fascinating organisms to study. It is true that fungi may interfere with human lives as agents of disease, and reduce yields of food crops. However, one fungal product has saved more lives than any other modern medical miracle except perhaps vaccinations, penicillin.

I came across this article recently, about the banning of yellow ribbons to honor soldiers in Litchfield, Connecticut. The reasons the town council gave for banning the ribbons were ridiculously flimsy. One reason was that the ribbons may cause a tree-killing fungus. This is absolute rubbish. Once again, fungi are being used as a scapegoat, and thankfully the citizens are not amused.

Some more fungal news

I've been slacking again. I just got back from a visit with my folks in Charlottesville, VA, where I had few fungal adventures, other than finding this lovely oyster mushroom growing on a tree on the Lawn of the UVa campus.

What else has been going on? Well, for one thing, Morrissey, former singer for the Smiths, decided he would launch into a tirage against Aer Lingus, calling it Aer Fungus. Grrr, why? Such a feeble insult! Clearly he knows little about the wonderful world of fungi.

In other news, a prime specimen of the white truffle was purchased by a Philadelphia restaurant for $4,100. The truffle weighed in at over a pound, and was found in Italy. You can see the fungal nugget in all its glory in this YouTube video.


Perhaps I should be looking for a job in the UK? A 90% drop in the number of mycologists may lead to more mushroom poisonings, according to this article.

And finally, an investigation into the abundance of fungi in mammoth dung has provided evidence that the decline of their populations was long and drawn out, not precipitous as would be expected in a meteor-caused extinction.

This day in fungal history and other fungal news

So it's been a while since I mentioned any fungi in the news, but I thought this tidbit of fungal history merited mention. On this day in 1931, an outbreak of Dutch elm disease was reported in the Greater New York area. The causal agent, Ophiostoma ulmi (and later O. novo-ulmi as well) is an exotic fungus, and the naive elm hosts are killed in great numbers. The name of the disease comes from the nation where the earliest research was conducted. There isn't a "Dutch elm", and the agent is not from the Netherlands. The fungus currently pictured at right is a Leptographium, a closely related group of fungi.

Fungi are also getting a lot of press for the diseases they are causing in the animal kingdom. Frog populations have been in decline due to chytridiomycosis, and bats are getting hammered by white nose syndrome, caused by another fungus, Geomyces sp. The risk has prompted closure of several of Alabama's caves.

In happier news, a violin made of fungus-infected wood outplayed a Stradivarius (they don't mention WHICH fungi). Previously I had blogged an article which suggested that Stradivari used fungus-infested wood to produce his masterpieces.

And finally, a fungus, Metarhizium, may be enlisted to help fight varroa mites, which have been linked to honeybee decline.